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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Chlorambucil therapy in children with steroid-resistant nephrotic syndrome
Chlorambucil therapy in children with steroid-resistant nephrotic syndrome
Document Language
:
English
Abstract
:
Chlorambucil (CHL) had been used as treatment for childhood nephrotic syndrome (NS) for more than half a century.1 It was used mainly in children with steroid sensitive nephrotic syndrome (SSNS) as steroid sparing agent in those with frequent relapsing or steroid dependent course.2 However, it was observed to result in higher rates of severe side effects and recommended as a second line drug after cyclophosphamide (CYC), which is considered as safer alkylating agent.2 The alkylating agents have been used for treating steroid resistant nephrotic syndrome (SRNS).2 However, CYC was used in most of the studies,3 while CHL was used only rarely.4,5 Elzouki et al showed in a small study that CHL induced complete or partial remission in patients with SRNS caused by either focal segmental glomerulosclerosis (FSGS) or mesangial proliferative glomerulonephritis (MPGN).4 In this retrospective study, we report our results of using CHL in children with SRNS secondary to IgM nephropathy, FSGS or diffuse mesangial hypercellularity (DMH).
ISSN
:
1658-3175
Journal Name
:
Saudi Medical Journal
Volume
:
27
Issue Number
:
4
Publishing Year
:
1427 AH
2006 AD
Article Type
:
Article
Added Date
:
Sunday, March 16, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
جميلة قاري
Kari, Jameela
Investigator
Doctorate
حماد الشايع
Alshaya, Hammad
Researcher
Doctorate
Files
File Name
Type
Description
Chlorambucil20051035[1].pdf
pdf
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