Main Page
About us
About the deanship
Vision
Mision
Quality policy
Deanship booklet
Research strategic construction
Employee list
Deanship consultants
Deanship agencies
Vice deanship for research groups
Vice deanship for research
Vice deanship of scientific research female
Research groups
Internal research programs
External research programs
Research groups prorgams
About research group programs
Active research groups
Guidelines for creating a new research group
Researcher services
Scientific instrument facilitating the publication
Abhathi portal
Plagiarism detection programs
Scientific journals
Research program forms
Researchers' inquiries
Research & scientific outcome
Digital media
Instruction guidelines
Research production for institutional finance
Activities & awards
Knowledge excellence awards
Knowledge excellence awards
Knowledge excellence awards winners
Excellence reward
Scientific research week
The fourteenth scientific research week
عربي
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Scientific Research
Document Details
Document Type
:
Project
Document Title
:
The Preventive and Therapeutic Role of Curcumin in Liver
الدور الوقائي و العلاجي للكركم في تليف الكبد
Subject
:
The Preventive and Therapeutic Role of Curcumin in Liver
Document Language
:
Arabic
Abstract
:
Chronic liver disease constitutes a major health problem in the Kingdom of Saudi Arabia. Hepatic fibrosis or cirrhosis is emerging as a treatable complication of chronic liver disease, following significant progress in understanding its underlying mechanisms. Efforts have focused on the hepatic stellate cells (HSC), as these cells can undergo, “activation” into proliferation and fibrogenic myofibroblast-like cells during liver injury. Disease-specific fibrogenic mechanisms have also include direct stimulation of stellate cell as by viral infections in hepatitis C and elevated leptin levels in non-alcoholic steatohepatitis (NASH). Antifibrotic therapies could become important in treating the millions of patients with chronic fibrosing liver disease. Curcumin the major polyphenolic compound in tumeric has been shown to attenuate hepatic damage. So, the present study was designed to assess the efficacy of curcumin intake in preventing thioacetamide-induced hepatic cirrhosis and to unravel the mechanism of its potential effect: is it a direct effect on HSC and collagen formation or an indirect effect by prevention of inflammation and necrosis. Four groups of rats will be used throughout this study. Group I (Control group) rats will receive the solvent at identical amount and duration. Liver cirrhosis will be induced in Groups II, III, and VI by thioacetamide (TAA; 200mg/kg, ip) twice weekly for 12 weeks. Group II (Cirrhosis group): untreated group. Group III (Prevention group): rats will receive curcumin (300 mg/kg/day, by gavage for 12 weeks) concomitantly with TAA. Group IV (Treatment group): rats will be given curcumin for 6 weeks after TAA discontinuation. Specimens from the liver will be processed for paraffin sections and stained with Hx&E and Masson Trichrome stain. Alpha smooth muscle actin expressed immunohistochemically by HSC will be considered a marker of their activation to myofibroblast. Nitrotyrosine level will be assessed in liver as a measure of oxidative stress. Image analyzer will be used to analyze the results morphometrically. Also, statistical analysis of the results will be determined by ANOVA test.
Publishing Year
:
1428 AH
2007 AD
Sponsor Name
:
King Abdulaziz University
Sponsorship Year
:
1428 AH
2007 AD
Added Date
:
Monday, June 28, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أميرة حسن الحجاج علي الحجاجي
El-Haggagy, Amira Ali
Investigator
Doctorate
Files
File Name
Type
Description
27174.docx
docx
Back To Researches Page