Document Details
|
Document Type |
: |
Thesis |
|
Document Title |
: |
cEffects of oral glucosamine sulphate on the glucose and lipids metabolism in rats تأثيرات التناول الفمي للجلوكوز أمين سلفات على ايض الجلوكوز والدهون في الفئران |
|
Subject |
: |
Faculty Of Science |
|
Document Language |
: |
Arabic |
|
Abstract |
: |
Glucosamine sulphate (GS) is a widely consumed dietary supplement as treatment for osteoarthritis, a condition associated with both obesity and type 2 diabetes mellitus (NIDDM). It is not regulated by the Food and Drug Administration. Therefore, concern has been raised about the possibility that glucosamine may have adverse effects on glucose and lipids metabolism. The aim of the present study was to determine if oral glucosamine sulphate (normal or high levels) had any effect on glucose and lipids metabolism in non-diabetic and type 2 diabetic rats. Seventy-two Wister male rats were divided into six groups. Three groups were nondiabetic and the other three were diabetic. Each of non-diabetic or diabetic groups received zero, normal and high levels of glucosamine sulphate (zero, 300 and 600 mg kg- 1 day-1, respectively) for six weeks. In diabetic rats, the high level of GS caused a significant elevation in serum levels of glucose, insulin, total cholesterol and triacylglycerol, while, the normal level of GS was able to significantly increase the serum total cholesterol level. However, in non-diabetic rats, high or normal levels of GS did not have any effects on the serum levels of glucose, insulin, total cholesterol and triacylglycerol, but, serum glucose and insulin levels were close to the diabetic ones. High and normal levels of GS did not have any effects on the serum levels of HDL- and LDL-cholesterols in either non-diabetic or diabetic rats. This study indicated that oral GS supplementation resulted in remarkable alterations in serum glucose, insulin, total cholesterol and triacylglycerol levels in diabetic rats, and this effect was greater with the high than the normal level of GS. But in non-diabetic groups, these effects were not significant. Thus, this study suggested that the GS should be applied with caution in (NIDDM) patients. |
|
Supervisor |
: |
Dr. Karima S. Mohamed |
|
Thesis Type |
: |
Master Thesis |
|
Publishing Year |
: |
1431 AH
2010 AD |
|
Number Of Pages |
: |
100 |
|
Co-Supervisor |
: |
Prof. Dr. Jalalueddin A. Jalal Khan |
|
Added Date |
: |
Tuesday, December 14, 2010 |
|
Researchers
| رشا أحمد باخدلقي | Bakhadlagi, Rasha Ahmed | Researcher | Master | |
|
Back To Researches Page
|